低分子肝素联合尿激酶或吲哚布芬在血液透析患者长期留置中心静脉导管中的应用

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Abstract Objective This study aimed to investigate the effect of low molecular weight heparin combined with urokinase or low molecular weight heparin combined with oral Indobufen in the sealing of central venous catheter in hemodialysis patients. Methods A total of 42 hemodialysis patients with central venous catheterization were divided into the control group (low molecular weight heparin, n=14), research group A (low molecular weight heparin combined with urokinase, n=14), and research group B (low molecular weight heparin combined with oral Indobufen, n=14). The catheter permeability, coagulation index, and the incidence of catheter adverse events were compared between the control group and research group A/B. Results Compared with the control group, the research group A was present with higher blood flow, urea clearance index, PT, APTT, and INR, and lower venous pressure and FIB. Compared with the control group, the research group B was present with higher blood flow, urea clearance index, PT, APTT, and INR, and lower venous pressure and FIB. There is a significant difference in the incidence of adverse events between the control group and study group A or between the control group and study group B. Conclusion The strategy of low molecular weight heparin combined with urokinase or low molecular weight heparin combined with oral Indobufen was effective in the sealing of central venous catheter in hemodialysis patients.

Key words： low molecular weight heparin urokinase indobufen hemodialysis central venous catheter

Received: 30 March 2023

PACS:	R692.5
	R459.5

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	Articles by authors
	LIAO Yilin
	Qin Wenyi
	LAN Ying
	WEI Zhaokai

Cite this article:

LIAO Yilin,Qin Wenyi,LAN Ying等. Application of Low Molecular Weight Heparin Combined with Urokinase or Oral Indobufen in the Sealing of Central Venous Catheter in Hemodialysis Patients[J]. HuNan ShiFan DaXue XueBao(YiXueBan), 2023, 20(5): 107-110.

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http://yxb.hunnu.edu.cn/EN/ OR http://yxb.hunnu.edu.cn/EN/Y2023/V20/I5/107

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