Comparison of effects of early fluid resuscitation at different rates on hemodynamics and prognosis of initially assessed non-severe acute pancreatitis
WU Pengyu1, LIU Jun1,2, SHAN Jing1, LIU Li1, PU Wenjing1, XUE Mei1, SUN Xiaobin1, WANG Qiong1
1. Department of Gastroenterology, Chengdu Third People's Hospital, Chengdu 610031, China; 2. Department of Gastroenterology, Sichuan Forestry Central Hospital, Chengdu 610084, China
Abstract：Objective To investigate the application effects of different rates of early fluid resuscitation on patients with non-severe acute pancreatitis (NSAP) at initial assessment. Methods The clinical data of 336 patients with NSAP at initial assessment were retrospectively analyzed. According to the early fluid infusion rate, the patients were divided into high-rate fluid infusion group (191 cases, total fluid resuscitation at 24 h >1/2 of total fluid resuscitation at 48 h after admission) and low-rate fluid infusion group (145 cases, total fluid resuscitation at 24 h ≤1/2 of total fluid resuscitation at 48 h after admission). The total fluid infusion at 24 h, 48 h and 72 h after admission was recorded in the two groups, and the changes in peripheral blood biochemical indicators [C-reactive protein (CRP), hematocrit (HCT), serum creatinine (Cre) ] were compared at 12 h, 48 h, 72 h, and 7 d after admission. The prognosis were analyzed in the two groups of patients. Results The total fluid infusion at 24 h and 48 h after admission in high-rate fluid infusion group was significantly higher than that in low-rate fluid infusion group (P<0.05), and the CRP and HCT levels at 12 h after admission and CRP level at 72 h after admission, time of vital signs reaching the standard, incidence rate of systemic inflammatory response syndrome (SIRS), incidence rate of multiple organ dysfunction syndrome (MODS), rate of invasive (interventional) operation, mechanical ventilation rate, rate of intensive care treatment and rate of conversion to severe condition were significantly lower than those in low-rate fluid infusion group (P<0.05). Conclusion High-rate fluid infusion is beneficial to improving the hemodynamics and prognosis of patients with NSAP at initial assessment, with high clinical application value.
武鹏宇, 刘俊, 单晶, 刘莉, 蒲玟静, 雪梅, 孙晓滨, 王琼. 不同速率早期液体复苏对初始评估未达重症标准急性胰腺炎血流动力学及预后的影响[J]. 金宝搏官方188学报(医学版), 2023, 20(1): 57-60.
WU Pengyu, LIU Jun, SHAN Jing, LIU Li, PU Wenjing, XUE Mei, SUN Xiaobin, WANG Qiong. Comparison of effects of early fluid resuscitation at different rates on hemodynamics and prognosis of initially assessed non-severe acute pancreatitis. HuNan ShiFan DaXue XueBao(YiXueBan), 2023, 20(1): 57-60.
2023, Vol. 20 
