涎液化糖链抗原6对判定新型冠状病毒感染严重程度的荟萃分析

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摘要目的:涎液化糖链抗原6（krebs von den lungen-6,KL-6）是一种主要由II型肺泡上皮细胞和分泌的糖蛋白,血液中KL-6水平与新冠病毒感染患者严重程度似乎存在相关性。因此,我们进行了荟萃分析,旨在评估血清KL-6水平在判定新冠病毒感染患者严重程度中的作用。方法:在PubMed、the Cochrane Library、中国知网（CNKI）、万方医学数据库检索2019年12月—2022年12月的相关文献。共纳入9项研究,随后使用RevMan 5.4及Stata 17.0进行汇总整合及分析。结果:9项研究中重症患者的血清KL-6显著高于轻中症患者（SMD=1.14,95%CI：0.79~1.49）。4项研究中计算的综合诊断参数为：灵敏度0.63（95%CI：0.51~0.75）;特异度0.88（95%CI：0.84~0.91）;阳性似然比为5.23（95%CI：3.99~6.85）;阴性似然比0.42（95%CI：0.30~0.57）;受试者工作特征曲线下面积：0.87。结论:在新冠病毒感染病程较重的患者中,KL-6水平显著升高,这表明KL-6可能是识别严重新冠病毒感染患者风险的有效检测指标。

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	杨佳璐
	尤倩
	彭倩
	吴意

关键词：涎液化糖链抗原6,新冠病毒感染,荟萃分析

Abstract：ObjectiveKrebs von den Lungen-6(KL-6) is a glycoprotein mainly secreted by type II alveolar epithelial cells. Blood levels of KL-6 appear to be correlated with the severity of COVID-19 patients. Therefore, we conducted a meta-analysis in this paper to assess the role of serum KL-6 levels in determining the severity of COVID-19 patients.MethodsThe relevant literatures from December 2019 to December 2022 were searched in PUBMED, the Cochrane Library, CNKI and Wanfang Medical database. A total of 9 studies were included and pooled in the meta-analysis. Use RevMan 5.4 and Stata 17.0 for summary, integration and analysis.ResultsSerum KL-6 in severe patients was significantly higher than that in mild patients in 9 studies (SMD=1.14, 95%CI: 0.79-1.49). The composite diagnostic parameters calculated in the four studies were sensitivity 0.63(95% CI: 0.51 - 0.75), specificity 0.88(95% CI: 0.84 - 0.91), positive likelihood ratio 5.23(95% CI: 3.99- 6.85), negative likelihood ratio 0.42(95% CI: 0.30 - 0.57), and area under the receiver operating characteristic curve 0.87.ConclusionKL-6 levels were significantly elevated in patients with a more advanced course of COVID-19, suggesting that KL-6 may be an effective test for identifying risk in patients with severe COVID-19.

Key words：krebs von den lungen-6 COVID-19 meta-analysis

收稿日期:2023-02-16

中图分类号:

R511

基金资助:长沙市科技计划项目（kh2201256）

通讯作者:吴意,E-mail：wuyi19701210@sina.com

引用本文:

杨佳璐, 尤倩, 彭倩, 吴意. 涎液化糖链抗原6对判定新型冠状病毒感染严重程度的荟萃分析[J]. 金宝搏官方188学报(医学版), 2023, 20(4): 65-70. YANG Jialu, YOU Qian, PENG Qian, WU Yi. A meta-analysis of Krebs von den Lungen-6 to determine the severity of COVID-19. HuNan ShiFan DaXue XueBao(YiXueBan), 2023, 20(4): 65-70.

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http://yxb.hunnu.edu.cn/CN/或http://yxb.hunnu.edu.cn/CN/Y2023/V20/I4/65

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