中国中老年人胰岛素抵抗代谢评分与新发脑卒中相关性研究

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摘要目的：探讨中老年人胰岛素抵抗代谢评分（METS-IR）与新发脑卒中之间的关系。方法：数据来源于2011年至2018年的中国健康与养老追踪调查（CHARLS）的数据。建立回归模型探究METS-IR与新发脑卒中之间的关联,同时采用限制立方样条模型来检查可能的非线性关联,并且采用亚组分析探究可能的潜在的调节变量。结果：研究共纳入6706名研究对象,其中新发脑卒中381人,回归模型结果发现METS-IR每上升一个四分位数,新发生脑卒中的患病风险增加67.3%（OR=1.673,95%CI：1.440~1.944）。使用限制性三次样条回归分析显示METS-IR与新发脑卒中患病率之间存在线性的相关关系,分层分析结果发现METS-IR与新发脑卒中的关系在不同亚组中一致。结论：METS-IR与新发脑卒中患病率密切相关,高METS-IR的人群需要更加警惕发生脑卒中的风险。

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关键词：胰岛素抵抗代谢评分,脑卒中,相关性研究,中国健康与养老追踪调查

Abstract：ObjectiveStroke is a major cause of cardiovascular mortality and may have a correlative relationship with insulin resistance. To investigate the relationship between the metabolic score for insulin resistance (METS-IR) and new-onset stroke in middle-aged and elderly people based on a large cohort study.MethodsData were obtained from the China Health and Retirement Longitudinal Study (CHARLS) in 2011 and 2018. Regression models were developed to explore the association between METS-IR and new-onset stroke, while restricted cubic spline models were used to examine possible nonlinear associations and subgroup analyses were used to explore possible potential moderating variables.ResultsA total of 6706 study subjects were included in the study, including 381 with new-onset stroke. The regression model results found a 67.3% increase in the risk of new-onset stroke for each quartile increase in the METS-IR (OR=1.673, 95% CI: 1.440-1.944). A linear relationship between the METS-IR and the prevalence of new-onset stroke was shown using restricted three-sample regression analysis, and stratified analysis revealed that the relationship between METS-IR and new-onset stroke was consistent across subgroups.ConclusionThe METS-IR is strongly associated with the prevalence of new-onset stroke, and people with high METS-IR need to be more alert to the risk of stroke.

Key words：METS-IR stroke association study CHARLS

收稿日期:2023-07-30

中图分类号:

R743.3

基金资助:辽宁省教育厅2020年度科学研究经费资助项目（FWZR2020004）

通讯作者:于洋,E-mail：yuyang@cmu1h.com

引用本文:

沙鸥, 于洋. 中国中老年人胰岛素抵抗代谢评分与新发脑卒中相关性研究[J]. 金宝搏官方188学报(医学版), 2023, 20(5): 70-74. SHA Ou, YU Yang. Association study between Metabolic Insulin Resistance Score and New-Onset Stroke in middle-aged and elderly Chinese population. HuNan ShiFan DaXue XueBao(YiXueBan), 2023, 20(5): 70-74.

链接本文:

http://yxb.hunnu.edu.cn/CN/或http://yxb.hunnu.edu.cn/CN/Y2023/V20/I5/70

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