TGF-β1、IFN-γ与Lund-Mackay评分在慢性鼻-鼻窦炎伴鼻息肉患者中表达意义及相关性研究

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摘要目的：探讨慢性鼻-鼻窦炎伴鼻息肉（CRSwNP）患者转化生长因子β1（TGF-β1）、干扰素-γ（IFN-γ）表达与Lund-Mackay评分关系及意义。方法：选取2020年1月―2021年10月我院CRSwNP患者98例作为研究对象,对比不同分期患者息肉组织TGF-β1、IFN-γ表达、Lund-Mackay评分,Pearson相关系数分析TGF-β1、IFN-γ表达与Lund-Mackay评分关系,COX回归模型分析CRSwNP复发的独立危险因素。受试者工作特征（ROC）曲线分析TGF-β1、IFN-γ表达对术后复发的评估价值,并采用决策曲线分析（DCA）比较TGF-β1、IFN-γ单独与联合评估的临床获益情况。结果：随着患者分期增加,TGF-β1表达降低,IFN-γ表达、Lund-Mackay评分升高;TGF-β1表达与Lund-Mackay评分呈负相关,IFN-γ表达与Lund-Mackay评分呈正相关;术后复发患者变应性鼻炎、合并哮喘、术后感染、Lund-Mackay评分、白细胞计数、嗜酸性粒细胞、TGF-β1、IFN-γ高于未复发患者;校正变应性鼻炎、合并哮喘、术后感染、白细胞计数、嗜酸性粒细胞后,TGF-β1、IFN-γ仍是CRSwNP患者术后复发的独立影响因素;TGF-β1、IFN-γ联合评估CRSwNP患者术后复发的AUC大于单独评估效能;在阈值0.18~0.82范围内,TGF-β1、IFN-γ联合评估模型评估CRSwNP患者术后复发的净受益率优于单独检测。结论：CRSwNP患者息肉组织TGF-β1、IFN-γ表达与病情密切相关,通过检测二者水平可判断患者术后复发风险,且联合检测患者受益率更高。

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关键词：鼻窦炎,鼻息肉,转化生长因子β1,干扰素-γ,Lund-Mackay评分

Abstract：ObjectiveTo investigate the relationship and significance of the expression of transforming growth factor β1(TGF-β1), interferon-γ (IFN-γ) and Lund-Mackay score in patients with chronic rhinosinusitis with nasal polyps (CRSwNP).MethodsA total of 98 patients with CRSwNP in our hospital from January 2020 to October 2021 were selected as the research subjects. The expression of TGF-β1, IFN-γ and Lund-Mackay score in polyp tissues of patients with different stages were compared. The Pearson correlation coefficient was used to analyze the relationship between the expression of TGF-β1 and IFN-γ and the Lund-Mackay score. COX regression model was used to analyze the independent risk factors of CRSwNP recurrence. Receiver operating characteristic (ROC) curve was used to analyze the evaluation value of TGF-β1 and IFN-γ expression on postoperative recurrence, and decision curve analysis (DCA) was used to compare the clinical outcomes of TGF-β1 and IFN-γ alone and in combination. benefit situation.ResultsWith the increase of patient stage, the expression of TGF-β1 decreased, the expression of IFN-γ and Lund-Mackay score increased (P<0.05). The expression of TGF-β1 was negatively correlated with the Lund-Mackay score, and the expression of IFN-γ was positively correlated with the Lund-Mackay score (P<0.05). The allergic rhinitis, combined asthma, postoperative infection, Lund-Mackay score, white blood cell count, eosinophils, TGF-β1 and IFN-γ in patients with postoperative recurrence were higher than those in patients without recurrence (P<0.05). After adjusting for allergic rhinitis, concurrent asthma, postoperative infection, white blood cell count, and eosinophils, TGF-β1 and IFN-γ were still independent influencing factors of postoperative recurrence in patients with CRSwNP (P<0.05). The combined AUC of TGF-β1 and IFN-γ to evaluate postoperative recurrence in CRSwNP patients was greater than the efficacy of independent evaluation (P<0.05). Within the threshold range of 0.18 to 0.82, the combined evaluation model of TGF-β1 and IFN-γ was better than the single test in evaluating the net benefit rate of postoperative recurrence in patients with CRSwNP.ConclusionThe expression of TGF-β1 and IFN-γ in polyp tissue of CRSwNP patients is closely related to the disease condition. The risk of postoperative recurrence can be judged by detecting the levels of the two, and the benefit rate of patients is higher by the combined detection.

Key words：sinusitis nasal polyps transforming growth factor beta 1 interferon-gamma Lund-Mackay score

收稿日期:2022-06-29

中图分类号:

R765.4

基金资助:喀什地区应用技术与开发计划项目（KS2021084）

通讯作者:代红英,E-mail：daihongying7008@126.com

引用本文:

代红英, 郭瑾瑾, 唐敏. TGF-β1、IFN-γ与Lund-Mackay评分在慢性鼻-鼻窦炎伴鼻息肉患者中表达意义及相关性研究[J]. 金宝搏官方188学报(医学版), 2023, 20(5): 56-60. DAI Hongying, GUO Jinjin, TANG Min. Expression significance and correlation of TGF-β1, IFN-γ and Lund-Mackay score in CRSwNP patients. HuNan ShiFan DaXue XueBao(YiXueBan), 2023, 20(5): 56-60.

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http://yxb.hunnu.edu.cn/CN/或http://yxb.hunnu.edu.cn/CN/Y2023/V20/I5/56

[1] De Corso E, Bilò MB, Matucci A, et al.Personalized Management of Patients with Chronic Rhinosinusitis with Nasal Polyps in Clinical Practice: A Multidisciplinary Consensus Statement[J]. J Pers Med, 2022, 12(5): 846.
[2] Bachert C, Han JK, Wagenmann M, et al.EUFOREA expert board meeting on uncontrolled severe chronic rhinosinusitis with nasal polyps (CRSwNP) and biologics: Definitions and management[J]. J Allergy Clin Immunol, 2021, 147(1): 29-36.
[3] 赖闻, 田松明, 张万杰, 等. 鼻内镜手术治疗慢性鼻-鼻窦炎伴鼻息肉的疗效观察[J]. 局解手术学杂志, 2019, 28(4): 307-310.
[4] 周兵, 张罗. 不断改进内镜鼻窦外科技术提高慢性鼻窦炎伴鼻息肉的疗效[J]. 中华耳鼻咽喉头颈外科杂志, 2021, 56(1): 7-10.
[5] 矫健, 张罗. 转化生长因子-β1对慢性鼻-鼻窦炎伴鼻息肉上皮紧密连接屏障功能的影响[J]. 首都医科大学学报, 2018, 39(1): 45-50.
[6] 王宝凤. IFN-γ诱导自噬不足通过p62蛋白引起慢性鼻-鼻窦炎中上皮细胞凋亡的研究[D]. 武汉: 华中科技大学, 2016.
[7] 中华耳鼻咽喉头颈外科杂志编辑委员会鼻科组, 中华医学会耳鼻咽喉头颈外科学分会鼻科学组. 中国慢性鼻窦炎诊断和治疗指南 (2018)[J]. 中华耳鼻咽喉头颈外科杂志, 2019, 54(2): 81-100.
[8] Vlaminck S, Vauterin T, Hellings PW, et al.The importance of local eosinophilia in the surgical outcome of chronic rhinosinusitis: a 3-year prospective observational study[J]. Am J Rhinol Allergy, 2014, 28(3): 260-264.
[9] Kariya S, Okano M, Higaki T, et al.Lund-Mackay Computed Tomography Score Is Associated With Obstructive Pulmonary Function Changes in Chronic Cough Patients[J]. Am J Rhinol Allergy, 2019, 33(3): 294-301.
[10] Stevens WW, Schleimer RP, Kern RC.Chronic Rhinosinusitis with Nasal Polyps[J]. J Allergy Clin Immunol Pract, 2016, 4(4): 565-572.
[11] Hopkins C.Chronic Rhinosinusitis with Nasal Polyps[J]. N Engl J Med, 2019, 381(1): 55-63.
[12] 吴鸿泉, 刘展, 覃宇铭. 慢性鼻-鼻窦炎伴鼻息肉患者鼻内镜术后复发的危险因素及相关模型构建[J]. 中国耳鼻咽喉颅底外科杂志, 2021, 27(5): 559-564.
[13] 赵宁, 王亚莉, 祁顺来. 慢性鼻-鼻窦炎伴鼻息肉患者鼻内镜术后炎症细胞及因子表达与术后复发的关系[J]. 中国医刊, 2021, 56(2): 173-177.
[14] 侯军才. 结合鼻窦CT评分联合血清变应原sIgE构建嗜酸粒细胞型CRSwNP患者术后复发的风险模型[J]. 临床耳鼻咽喉头颈外科杂志, 2022, 36(01): 19-24.
[15] 李艺敏, 谭国静, 江雨, 等. TGF-β1/Smads通路在体外培养的鼻息肉组织重构中的作用[J]. 上海交通大学学报 (医学版), 2019, 39(7): 737-743.
[16] Li X, Li C, Zhu G, et al.TGF-β1 Induces Epithelial-Mesenchymal Transition of Chronic Sinusitis with Nasal Polyps through MicroRNA-21[J]. Int Arch Allergy Immunol, 2019, 179(4): 304-319.
[17] 陈璐, 肖玲, 杨玉成. AhR、TGF-β1在伴或不伴鼻息肉的慢性鼻窦炎中的表达分析[J]. 基因组学与应用生物学, 2018, 37(5): 2150-2156.
[18] 张洁, 胡彦辉. 老年鼻窦炎患者鼻腔结构异常与IFN-γ、IL-5、IL-17相关性分析[J]. 实验与检验医学, 2019, 37(4): 713-716.
[19] Avdeeva K, Fokkens W.Precision Medicine in Chronic Rhinosinusitis with Nasal Polyps[J]. Curr Allergy Asthma Rep, 2018, 18(4): 25.
[20] 刘莹莹, 卢义, 孙敏, 等. 炎症因子TGF-β1、IFN-γ在冠心病患者中的表达及意义[J]. 中国免疫学杂志, 2015, 33(3): 404-405.
[21] 杨光. 变应性因素与鼻息肉发病的关系[D]. 天津: 天津医科大学, 2019.
[22] 吴湘明, 冯勇军, 曾春荣, 等. 老年慢性鼻-鼻窦炎伴鼻息肉患者鼻内镜术后复发的影响因素分析[J]. 中国耳鼻咽喉头颈外科, 2021, 28(1): 38-40+44.
[23] 潘泽如, 陈红先, 詹淑洁. 慢性鼻-鼻窦炎伴鼻息肉患者鼻内镜术后鼻息肉复发的影响因素[J]. 医学综述, 2021, 27(13): 2695-2699.
[24] 王彤, 臧洪瑞, 李云川, 等. Smad信号通路在慢性鼻-鼻窦炎伴鼻息肉和不伴鼻息肉的黏膜上皮修复机制中的作用[J]. 临床耳鼻咽喉头颈外科杂志, 2019, 33(1): 9-13.
[25] Wang BF, Cao PP, Wang ZC, et al.Interferon-γ-induced insufficient autophagy contributes to p62-dependent apoptosis of epithelial cells in chronic rhinosinusitis with nasal polyps[J]. Allergy, 2017, 72(9): 1384-1397.