单侧全聋型突聋患者临床特征和血液学参数与预后的相关性研究

摘要
图/表
参考文献
相关文章 (7)

全文: PDF (2213 KB) HTML (0 KB)
输出: BibTeX | EndNote (RIS)

摘要 目的: 分析总结单侧全聋型突聋患者的临床特征以及实验室检查结果,探讨影响患者听力恢复的因素。方法: 搜集2019年9月―2022年10月在金宝搏官方188附属长沙市第四医院住院的单侧全聋型突聋患者的临床及实验室检查资料（共89例）,分析患者性别、年龄、患耳、发病至就诊时间、有无伴随症状（耳鸣、头晕、耳闷）、有无伴发疾病（高血压、糖尿病、心脏病、高脂血症）、以及血液学参数（中性粒细胞数、淋巴细胞数、纤维蛋白原、白蛋白、血脂）对预后的影响。结果: 单因素分析显示发病至就诊时间、性别、患耳、耳鸣、耳闷、高血压、糖尿病、心脏病、高脂血症与单侧全聋型突聋患者疗效无关;年龄≥40岁患者有效率为33.90%明显低于年龄<40岁的86.96%。伴眩晕者有效率为25%,低于不伴眩晕者的63.4%;单侧全聋型突聋患者中性粒细胞数、淋巴细胞数、血小板数、纤维蛋白原、白蛋白、甘油三酯、低密度脂蛋白、FAR、PLR、NLR与预后影响无明显相关性;而血总胆固醇、高密度脂蛋白有明显相关性;对年龄、眩晕、总胆固醇、高密度脂蛋白进行多因素Logistic 回归分析,发现年龄与单侧全聋型突聋患者预后无明显相关性,而眩晕、总胆固醇、高密度脂蛋白均显著相关。结论: 眩晕、总胆固醇、高密度脂蛋白是影响单侧全聋型突聋患者听力恢复的重要危险因素。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	石莹
	邓晓雯
	宋桂林

关键词 ：突发性耳聋, 全聋型, 血液学参数, 临床症状, 预后

Abstract：Objective To investigate the clinical characteristics and laboratory test results (such as hematological parameters) of patients with sudden unilateral total sensorineural hearing loss and to explore the factors affecting the curative effect of hearing recovery. Methods The clinical and laboratory examination data of 89 patients with sudden unilateral total sensorineural hearing loss hospitalized in Changsha Fourth Hospital Affiliated to Hunan Normal University from September 2019 to October 2022 were collected, and the gender, age, affected ears, time from onset to medical treatment, accompanied symptoms (tinnitus, dizziness, ear tightness), accompanied diseases (hypertension, diabetes, heart disease, hyperlipidemia) and the influence of hematological parameters (neutrophil number, lymphocyte number, fibrinogen, albumin, blood lipid) on prognosis. Results Univariate analysis showed that the time from onset to treatment, gender, affected ear, tinnitus, ear fullness, hypertension, diabetes, heart disease and hyperlipidemia were not related to the efficacy of patients with unilateral total sudden deafness. The effective rate of patients over 40 years old was 33.90%, which was significantly lower than 86.96% of patients under 40 years old. The effective rate of patients with vertigo was 25%, which was lower than 63.4% of patients without vertigo. Neutrophil count, lymphocyte count, platelet count, fibrinogen, albumin, triglyceride, low-density lipoprotein, FAR, PLR, NLR were not related to the prognosis of patients with unilateral total sudden deafness. There was a significant correlation between total cholesterol and high-density lipoprotein. Multivariate Logistic regression analysis of age, vertigo, total cholesterol and high-density lipoprotein showed that age was not related to the prognosis of patients with unilateral sudden deafness, while vertigo, total cholesterol and high-density lipoprotein were significantly related. Conclusion vertigo, total cholesterol and high-density lipoprotein are important risk factors for auditory recovery in patients with sudden unilateral total deafness.

Key words： sudden hearing loss total deafness hematological parameters clinical symptoms prognosis

收稿日期: 2022-11-28

中图分类号:

R764

通讯作者: 宋桂林, E-mail: 2601789055@qq. com

引用本文:

石莹, 邓晓雯, 宋桂林. 单侧全聋型突聋患者临床特征和血液学参数与预后的相关性研究[J]. 金宝搏官方188学报(医学版), 2023, 20(1): 97-100. SHI Ying, DENG Xiaowen, SONG Guilin. Correlation between clinical characteristics, hematological parameters and prognosis in patients with sudden unilateral total sensorineural hearing loss. HuNan ShiFan DaXue XueBao(YiXueBan), 2023, 20(1): 97-100.

链接本文:

http://yxb.hunnu.edu.cn/CN/ 或 http://yxb.hunnu.edu.cn/CN/Y2023/V20/I1/97

[1] 余力生, 杨仕明. 突发性聋诊断和治疗指南 (2015)[J]. 中华耳鼻咽喉头颈外科杂志, 2015, 50(06): 443-447.
[2] 顾文菁, 于红, 任大伟, 等. 突发性耳聋病因及其与内耳免疫学研究进展[J]. 中国老年学杂志, 2019, 39(23): 5860-5863.
[3] 王竹. 突发性耳聋与病毒感染的关系研究进展[J]. 首都食品与医药, 2022, 29(1): 18-19.
[4] 余力生, 杨仕明, 韩东一, 等. 中国突发性聋分型治疗的多中心临床研究[J]. 中华耳鼻咽喉头颈外科杂志, 2013(05): 355-361.
[5] 王月辉. 甲泼尼龙耳后注射联合巴曲酶治疗突发性耳聋的效果[J]. 中国实用医刊, 2021, 48(04): 93-96.
[6] 刘国英. 预见性告知护理对突发性耳聋伴耳鸣患者心理状态的影响研究[J]. 中国医学创新, 2018, 15(31): 68-71.
[7] Yamada S, Kita J, Shinmura D, et al.Update on Findings about Sudden Sensorineural Hearing Loss and Insight into Its Pathogenesis[J]. J Clin Med, 2022, 11(21): 6387.
[8] 王倩滢, 钟时勋. 巴曲酶在不同类型突发性耳聋治疗中的应用[J]. 中华耳科学杂志, 2018, 16(2): 239-243.
[9] 谌国会, 王洪阳, 高云, 等. 全聋型突发性聋患者的临床特征及转归分析[J]. 中华耳科学杂志, 2022, 20(2): 211-216.
[10] Shimanuki MN, Shinden S, Oishi N, et al.Early hearing improvement predicts the prognosis of idiopathic sudden sensorineural hearing loss[J]. Eur Arch Otorhinolaryngol, 2021, 278(11): 4251-4258.
[11] Byl F J.Sudden hearing loss: eight years' experience and suggested prognostic table[J]. Laryngoscope, 1984, 94(5 Pt 1): 647-661.
[12] 施紫光, 管明, 李勇. 年龄和治疗前听力对突发性聋治疗效果的影响[J]. 临床耳鼻咽喉头颈外科杂志, 2010, 24(1): 33-34.
[13] Blazer DG, Tucci DL.Hearing loss and psychiatric disorders: a review[J]. Psychol Med, 2019, 49(6): 891-897.
[14] 刘燕, 刘欢, 叶冬密, 等. 突发性耳聋患者心理状态的影响因素分析及其预见性护理策略[J]. 中西医结合护理 (中英文), 2022, 8(2): 193-195.
[15] 高云, 王大勇, 粟秦, 等. 伴眩晕的突发性聋患者的临床特征与疗效分析[J]. 中华耳鼻咽喉头颈外科杂志, 2015, 50(7): 529-535.
[16] 范林静, 索利敏, 董美, 等. 单侧全聋型突发性聋患者临床特征及预后分析[J]. 中国耳鼻咽喉颅底外科杂志, 2022, 28(4): 41-45.
[17] 孙菲, 周柯, 林颖, 等. 影响突发性聋患者预后的因素与疗效相关性分析[J]. 听力学及言语疾病杂志, 2018, 26(2): 195-198.
[18] 李倩, 王大勇, 王洪阳, 等. 突发性聋合并高血压病患者的纯音测听特征与疗效分析[J]. 临床耳鼻咽喉头颈外科杂志, 2015, 29(8): 748-752.
[19] Aimoni C, Bianchini C, Borin M, et al.Diabetes, cardiovascular risk factors and idiopathic sudden sensorineural hearing loss: a case-control study[J]. Audiol Neurootol, 2010, 15(2): 111-115.
[20] Shao M, Xiong G, Xiang G, et al.Correlation between serum lipid and prognosis of idiopathic sudden sensorineural hearing loss: a prospective cohort study[J]. Ann Transl Med, 2021, 9(8): 676.
[21] Padró T, Vilahur G, Badimon L.Dyslipidemias and Microcirculation[J]. Curr Pharm Des, 2018, 24(25): 2921-2926.
[22] 徐宏鸣, 翁婷雯, 董频. 突发感音神经性聋同血脂异常关系的研究进展[J]. 中华耳科学杂志, 2013(3): 461-463.
[23] Chang S L, Hsieh C C, Tseng K S, et al.Hypercholesterolemia is correlated with an increased risk of idiopathic sudden sensorineural hearing loss: a historical prospective cohort study[J]. Ear Hear, 2014, 35(2): 256-261.
[24] Chen C, Wang M, Wang H, et al.Impact of hyperlipidemia as a coexisting factor on the prognosis of idiopathic sudden sensorineural hearing loss: A propensity score matching analysis[J]. Clin Otolaryngol, 2020, 45(1): 2-11.
[25] Zhang X, Chen J, Gao Z, et al.Response of Glucocorticoid Receptor Alpha and Histone Deacetylase 2 to Glucocorticoid Treatment Predicts the Prognosis of Sudden Sensorineural Hearing Loss[J]. Clin Exp Otorhinolaryngol, 2019, 12(4): 367-375.
[26] 朱斌, 王春, 孟子珅, 等. 突发性聋患者血常规、血脂、血液流变学的水平及其与预后的相关性[J]. 中国中西医结合耳鼻咽喉科杂志, 2020, 28(1): 1-8, 55.
[27] 王楚, 冷辉. 平坦及全聋型突发性聋的血液参数与预后的相关研究[J]. 沈阳医学院学报, 2021, 23(6): 543-547.
[28] Lu Y, Yong J, Xia Y, et al. Multifactorial analysis of the degree of hearing loss and outcome in patients with sudden hearing loss[J]. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, 2022, 36(11): 827-834. Chinese.