外周血Th17/Treg相关细胞因子在卵巢癌中的预后评估价值

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摘要目的：探讨外周血辅助性T细胞17（Th17）/调节性T细胞（Treg）相关细胞因子在卵巢癌中的预后评估价值。方法：选取2018年7月―2020年6月广西桂林医学院第二附属医院收治的80例卵巢癌患者作为卵巢癌组,选取同期体检健康者50例为健康组;统计卵巢癌组患者随访3年内预后情况,复发、死亡为预后不良,无复发、生存者为预后良好。检测各组外周血Th17、Treg细胞百分率、白细胞介素（IL）-17与IL-10水平,计算Th17/Treg;比较卵巢癌组、健康组以及不同临床分期卵巢癌患者上述指标差异。采用Cox回归分析明确相关危险因素,并绘制ROC曲线验证Th17/Treg与IL-17、IL-10对卵巢癌预后的预测效能。结果：卵巢癌组患者外周血Th17、Treg细胞占比、Th17/Treg以及IL-17、IL-10水平均高于健康组患者。Ⅰ~Ⅱ期患者外周血Th17、Treg细胞占比、Th17/Treg以及IL-17、IL-10水平均低于Ⅲ~Ⅳ期患者。预后不良患者与预后良好患者比较,年龄、临床分期、残余病变大小、接受化疗疗程数、Th17、Treg、Th17/Treg、IL-17、IL-10差异具有统计学意义。多因素Cox回归分析结果显示,临床分期、残余病变大小、接受化疗疗程数、外周血Th17、Treg比例、Th17/Treg、IL-17、IL-10水平为卵巢癌患者预后的独立影响因素。ROC曲线结果显示,Th17/Treg、IL-17、IL-10及3项联合的ROC曲线下面积（AUC）分别为0.789、0.845、0.839、0.960。结论：Th17/Treg及其相关细胞因子如IL-17、IL-10水平的变化可能参与卵巢癌的发生与发展,并与患者预后情况密切相关,对预后具有一定的预测价值。

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	雷小妹
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关键词：辅助性T细胞17,调节性T细胞,卵巢癌,预后评估

Abstract：ObjectiveTo investigate the prognostic value of peripheral blood helper T cell 17（Th17）/ regulatory T cell（Treg）- related cytokines in ovarian cancer.MethodsA total of 80 patients with ovarian cancer admitted to the Second Affiliated Hospital of Guangxi Guilin Medical College from July 2019 to June 2021 were selected as the ovarian cancer group，and 50 healthy patients in the same period were selected as the healthy group. The prognosis of ovarian cancer patients during 3 years follow-up was analyzed. Recurrence and death were poor prognosis，while no recurrence and survivors were good prognosis. The percentage of Th17，Treg cells，interleukin-17（IL-17）and IL-10 in peripheral blood of each group were detected，and Th17/Treg was calculated. The above indexes were compared between ovarian cancer group，healthy group and ovarian cancer patients with different clinical stages. Cox regression analysis was used to identify related risk factors，and ROC curves were drawn to verify the prognostic efficacy of Th17/Treg，IL-17 and IL-10 in ovarian cancer.ResultsThe proportion of Th17 and Treg cells，Th17/Treg and IL-17 and IL-10 levels in peripheral blood of patients with ovarian cancer group were higher than those in healthy group. The proportion of Th17 and Treg cells，Th17/Treg and IL-17 and IL-10 levels in peripheral blood of patients with stage Ⅰ to Ⅱ were lower than those of patients with stage Ⅲ to Ⅳ. There were statistically significant differences in age，clinical stage，residual lesion size，number of chemotherapy courses，Th17，Treg，Th17/Treg，IL-17 and IL-10 between patients with poor prognosis and those with good prognosis. Multivariate Cox regression analysis showed that clinical stage，residual lesion size，number of chemotherapy courses，Th17，Treg ratio in peripheral blood，Th17/Treg，IL-17 and IL-10 levels were independent prognostic factors of ovarian cancer patients. ROC curve results showed that the area under ROC curve（AUC）of Th17/Treg，IL-17，IL-10 and the three combinations were 0.789，0.845，0.839 and 0.960，respectively.ConclusionThe changes of Th17 / Treg and its related cytokines，such as IL-17 and IL-10，may participate in the occurrence and development of ovarian cancer，and are closely related to the prognosis of patients，which has a certain predictive value for prognosis.

Key words：helper T cells17 regulatory T cells ovarian cancer prognostic assessment

收稿日期:2023-08-25

中图分类号:

R737.31

基金资助:广西壮族自治区卫生健康委员会科研课题（Z20190528）

通讯作者:雷小妹,E-mail：leixiaomei12345678@163.com

引用本文:

雷小妹, 阳华, 王莹, 蒙维华. 外周血Th17/Treg相关细胞因子在卵巢癌中的预后评估价值[J]. 金宝搏官方188学报(医学版), 2023, 20(5): 99-102. LEI Xiaomei, YANG Hua, WANG Ying, MENG Weihua. Prognostic value of Th17 / Treg related cytokines in peripheral blood in ovarian cancer. HuNan ShiFan DaXue XueBao(YiXueBan), 2023, 20(5): 99-102.

链接本文:

http://yxb.hunnu.edu.cn/CN/或http://yxb.hunnu.edu.cn/CN/Y2023/V20/I5/99

[1] 熊廷川,王迎洪,朱长军. PDGFRA调控p53信号通路介导卵巢癌细胞增殖、凋亡和侵袭的作用及机制[J]. 天津师范大学学报(自然科学版),2023,43(3):35-39+52.
[2] 林梦,赵益. 卵巢癌患者医患共同决策现状及影响因素分析[J]. 护理学杂志,2023,38(12):9-12.
[3] 陈玲,王衍,孙洪芳,等. 基于术前NLR、LMR及白蛋白的炎症预后指数评估上皮性卵巢癌患者预后的价值[J]. 现代肿瘤医学,2021,29(17):3069-3073.
[4] 袁风玲,贾淑慧,江源. 卵巢癌组织中PD-L1及PD-L2的表达及其预后判断价值[J]. 实用癌症杂志,2020,35(10):1622-1624+1638.
[5] 崔彭华,李志艳,张玉娟,等. 卵巢癌患者外周血免疫指标及炎性因子的检测及临床意义[J]. 中国计划生育学杂志,2018,26(11):1098-1101.
[6] Marchenko S,Piwonski I,Hoffmann I,et al.Prognostic value of regulatory T cells and T helper 17 cells in high grade serous ovarian carcinoma[J]. J Cancer Res Clin Oncol,2023,149(6):2523-2536.
[7] Kuroki L,Guntupalli SR.Treatment of epithelial ovarian cancer[J]. BMJ,2020,371:m3773.
[8] Penny SM.Ovarian Cancer:An Overview[J]. Radiol Technol,2020,91(6):561-575.
[9] Wang M,Chen B,Sun XX,et al.Gastric cancer tissue-derived mesenchymal stem cells impact peripheral blood mononuclear cells via disruption of Treg/Th17 balance to promote gastric cancer progression[J]. Exp Cell Res,2017,361(1):19-29.
[10] Wang Y,Xu G,Wang J,et al.Relationship of Th17/Treg Cells and Radiation Pneumonia in Locally Advanced Esophageal Carcinoma[J]. Anticancer Res,2017,37(8):4643-4647.
[11] Yang G,Li H,Yao Y,et al.Treg/Th17 imbalance in malignant pleural effusion partially predicts poor prognosis[J]. Oncol Rep,2015,33(1):478-484.
[12] 李元昆,崔金全,廖予妹,等. Treg和Th17在卵巢癌患者外周血中的意义及与预后的相关性分析[J]. 中国免疫学杂志,2020,36(23):2904-2907+2912.
[13] 贺欣,张目涵,路瑶,等. Th17/Treg相关因子对T84细胞单层模拟的肠黏膜屏障通透性的影响[J]. 中国免疫学杂志,2018,34(8):1137-1142.
[14] 李晓英,谢启超. 不同分期非小细胞肺癌与Treg细胞、细胞因子相关研究[J]. 安徽医科大学学报,2017,52(1):113-116.
[15] 王玲,王素梅,张继等. 卵巢癌患者CD4+ T淋巴细胞亚群Th17/Treg变化及影响预后的因素[J]. 中国卫生工程学,2022,21(01):158-159+162.
[16] 王丽华,王亮亮,张競,等. 卵巢癌患者外周血Th1/Th2及Treg/Th17细胞平衡关系[J]. 南方医科大学学报,2017,37(8):1066-1070.
[17] 李丽君,骆敏翔,赵昌林. 艾灸对肉瘤微环境中Treg/Th17平衡的调节作用[J]. 中华中医药杂志,2021,36(11):6752-6755.