Abstract：Objective To investigate the relationship and significance of the expression of transforming growth factor β1(TGF-β1), interferon-γ (IFN-γ) and Lund-Mackay score in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). Methods A total of 98 patients with CRSwNP in our hospital from January 2020 to October 2021 were selected as the research subjects. The expression of TGF-β1, IFN-γ and Lund-Mackay score in polyp tissues of patients with different stages were compared. The Pearson correlation coefficient was used to analyze the relationship between the expression of TGF-β1 and IFN-γ and the Lund-Mackay score. COX regression model was used to analyze the independent risk factors of CRSwNP recurrence. Receiver operating characteristic (ROC) curve was used to analyze the evaluation value of TGF-β1 and IFN-γ expression on postoperative recurrence, and decision curve analysis (DCA) was used to compare the clinical outcomes of TGF-β1 and IFN-γ alone and in combination. benefit situation. Results With the increase of patient stage, the expression of TGF-β1 decreased, the expression of IFN-γ and Lund-Mackay score increased (P<0.05). The expression of TGF-β1 was negatively correlated with the Lund-Mackay score, and the expression of IFN-γ was positively correlated with the Lund-Mackay score (P<0.05). The allergic rhinitis, combined asthma, postoperative infection, Lund-Mackay score, white blood cell count, eosinophils, TGF-β1 and IFN-γ in patients with postoperative recurrence were higher than those in patients without recurrence (P<0.05). After adjusting for allergic rhinitis, concurrent asthma, postoperative infection, white blood cell count, and eosinophils, TGF-β1 and IFN-γ were still independent influencing factors of postoperative recurrence in patients with CRSwNP (P<0.05). The combined AUC of TGF-β1 and IFN-γ to evaluate postoperative recurrence in CRSwNP patients was greater than the efficacy of independent evaluation (P<0.05). Within the threshold range of 0.18 to 0.82, the combined evaluation model of TGF-β1 and IFN-γ was better than the single test in evaluating the net benefit rate of postoperative recurrence in patients with CRSwNP. Conclusion The expression of TGF-β1 and IFN-γ in polyp tissue of CRSwNP patients is closely related to the disease condition. The risk of postoperative recurrence can be judged by detecting the levels of the two, and the benefit rate of patients is higher by the combined detection.
2023, Vol. 20 
