Research Advances in the Correlation Between Parkinson’s Disease and Intestinal Microbiota
1. School of Medicine, Hunan Normal University, Changsha 410013, Hunan, China; 2. The 3rd Xiangya Hospital, Central South University, Changsha 410013, Hunan, China; 3. The Ninth Hospital of Changsha, Changsha 410014, Hunan, China; 4. The Research Center of Reproduction and Translational Medicine of Hunan Province, School of Medicine, Hunan Normal University, Changsha 410013, Hunan, China
Abstract：Parkinson’s disease (PD) is a serious threat to the health of middle-aged and elderly people. The etiology of the disease remains unclear. Recent studies have found that the occurrence of PD is closely related to the intestinal microbiome, which is involved in the process of PD by affecting the intestinal barrier permea-bility, inflammation and oxidative stress levels and the release of neurotransmitters through the microbe-gut-brain axis. Dietary intervention, supplementation with suitable probiotics and fecal microbiota transplantation (FMT) can effectively alleviate or improve the symptoms of PD, and may be useful to treat the disease. However, due to the great heterogeneity of gut microbes, much work needs to be done to reveal the correlation between PD and intestinal microbiome.
许 龙, 雷立芳, 谭志霞, 廖旻晶, 蔡秀怡, 刘年猛, 叶湘漓. 帕金森病与肠道微生物群相关性的研究进展[J]. 生命科学研究, 2023, 27(6): 551-558. Xü Long, LEI Lifang, TAN Zhixia, LIAO Minjing, CAI Xiuyi, LIU Nianmeng, YE Xiangli. Research Advances in the Correlation Between Parkinson’s Disease and Intestinal Microbiota. Life Science Research, 2023, 27(6): 551-558.
