Abstract：Abstract: Long non-coding RNAs (lncRNAs) refer to a group of non-coding RNAs (ncRNAs) transcribed in eukaryotic cells with a length of more than 200 nucleotides. It is a basic part of the cellular gene regulatory network and is characterized by tissue specificity and conditional expression specificity. Previous studies have proved that lncRNAs are abundantly enriched in the central nervous system (CNS), show a complex tem-poral and spatial expression profile, and participate in the regulation of brain development in a variety of ways. In recent years, a growing number of studies have suggested that dysregulation or mutation of the lnc-RNA genes is closely related to a variety of CNS-related neurodegenerative diseases (NDDs), such as Alzhei-mer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS), Huntington disease (HD), amyotrophic lateral sclerosis (ALS), etc. This article summarizes the research progress of lncRNAs in NDDs in order to pro-vide new insights for understanding the etiology, pathological mechanism and targeted therapy of these di-seases.
引用本文:
武世萍, 俞 坤, 巩盼盼, 王满侠. 长链非编码RNA在神经退行性疾病中作用机制的研究进展[J]. 生命科学研究, 2022, 26(4): 341-348. WU Shi-ping, YU Kun, GONG Pan-pan, WANG Man-xia. Research Progress of Mechanisms of Long Non-coding RNAs in Neurodegenerative Diseases. Life Science Research, 2022, 26(4): 341-348.
