Abstract：Abstract: The cGAS-STING pathway is an innate immune mechanism that has been received extensive at-tention in recent years. Cytoplasmic DNA is recognized by cyclic GMP-AMP synthase (cGAS) and then cGAS catalyzes ATP and GTP to synthesize cyclic GMP-AMP (cGAMP). Subsequently, cGAMP binds to and acti-vates stimulator of interferon genes (STING), which induces a series of innate immune responses including production of typeⅠinterferons. More and more studies have shown that cGAS-STING pathway plays an im-portant role in infectious diseases, autoimmune diseases and tumor immunology. This review summarizes ac-tivation of cGAS-STING pathway and its immune response and mechanism in the defense against viruses, bacteria and parasites, hoping to find new targets for treatment of infectious diseases.
引用本文:
王 熙, 秦志强. cGAS-STING通路在抗感染免疫的研究进展[J]. 生命科学研究, 2022, 26(2): 145-150. WANG Xi, QIN Zhi-qiang. Research Progress of cGAS-STING Pathway in Anti-infection Immunity. Life Science Research, 2022, 26(2): 145-150.
