Abstract：Abstract: Hyperuricemia (HUA) is a common disease associated with the incidence and development of mul-tiple complications such as gouty arthritis, type 2 diabetes, cardiovascular disease, functional liver and kid-ney injuries. Long-term and stable induction is essential for HUA-associated complications in modeling ani-mals. Unlike in human, common model animals express high levels of uricase that decompose uric acid to soluble allantoin for renal excretion. This profile leads to insufficient daily exposure to high uric acid levels during modeling period. Therefore, the model animal selection, induction method and high uric acid duration are all causes that influence the observation of hyperuricemia-associated complications. Herein, the research progress in modeling of long-term chronic HUA animals and evaluation of the associated complications is reviewed. It mainly focuses on evaluation of current chemical inducers, selection of modeling animals and influence of genetic intervention, in order to provide information for modeling method selection in long-term chronic HUA research.
引用本文:
张乐琦, 林翠婷, 黄清华, 吴 婷, 杨 阳. 不同方法建立长期慢性高尿酸血症模型及对相关并发症影响的研究进展[J]. 生命科学研究, 2022, 26(2): 125-130. ZHANG Le-qi, LIN Cui-ting, HUANG Qing-hua, WU Ting, YANG Yang. Research Progress in Long-term Chronic Hyperuricemia Modeling Methods and Their Impacts on Associated Complications. Life Science Research, 2022, 26(2): 125-130.
