Abstract：Abstract: Epigenetic regulation is a key research field in the post-genomic era. There is a lot of evidence that epigenetic regulation controls the process of heart development and is involved in the occurrence of a variety of heart diseases. This review summarizes the roles of DNA methylation, histone modification and chromatin remodeling complex and microRNAs in the heart development, and the epigenetic mechanisms re-lated to heart diseases such as atherosclerosis, heart failure, myocardial ischemia, and myocardial fibrosis. The article also gives an overview of important roles of biologically active food compounds in cardiac protec-tion, providing a new perspective for the research on the molecular mechanism of heart development and the prevention and treatment of heart diseases.
引用本文:
袁婺洲, 张亚楠. 心脏发育和疾病的表观遗传调控机制[J]. 生命科学研究, 2022, 26(1): 1-12. YUAN Wu-zhou, ZHANG Ya-nan. Epigenetic Mechanisms Involved in Heart Development and Disease. Life Science Research, 2022, 26(1): 1-12.
