Abstract：Abstract: Small heterodimer partner (SHP) is a transcriptional inhibitor of gene expression that interacts with a wide variety of nuclear receptors and transcription factors and involves in multiple metabolic pathways, in-cluding bile acid, glucose and lipid metabolism. SHP is predominately expressed in the gallbladder and liver, and at lower levels in the adipose tissue and pancreas. In the liver, SHP is known to perform several metabolic functions. It regulates hepatic metabolism by modulating the expression of a series of genes related to cholesterol degradation, bile acid synthesis, gluconeogenesis and adipogenesis. Overexpression of SHP in the liver leads to depletion of hepatic bile acid pool and concomitant accumulation of triglycerides. SHP deletion in the liver of mice prevents the development of fatty liver. In adipose tissue, SHP overexpression predominantly increases glucose intolerance and exacerbates high-fat diet-induced obesity. In the pancreas, regulating the expression of SHP may affect glucose-stimulated insulin secretion and β-cell dysfunction caused by endoplasmic reticulum stress. In addition, the mutation of SHP is associated with obesity and most likely to increase the susceptibility to type 2 diabetes in a particular population. Herein, the mechanism of SHP regulating bile acid, glucose and lipid metabolism is focused, and recent findings are summarized to demonstrate the main physiological functions of SHP and its role in the development of type 2 diabetes.
引用本文:
吕秋月, 姜保平, 肖培根. 孤儿核受体小异二聚体伴侣在胆汁酸及糖脂代谢中的作用研究进展[J]. 生命科学研究, 2021, 25(3): 209-216. L?譈 Qiu-yue, JIANG Bao-ping, XIAO Pei-gen. Roles of Orphan Nuclear Receptor Small Heterodimer Partner in Bile Acid, Glucose and Lipid Metabolism. Life Science Research, 2021, 25(3): 209-216.
