Abstract��Abstract: MMP-28 is the latest member of the matrix metalloproteinase family and is widely expressed in organisms. It is usually secreted in the form of an inactive zymogen, and its activity is regulated in a variety of ways to maintain tissue homeostasis. MMP-28 has a variety of functions. It not only plays a vital role in the normal physiological processes of the human body, but also promotes the occurrence and progression of pathological processes such as tumors in various ways, such as inhibiting tumor cell apoptosis, promoting cancer tissue invasion and metastasis, and angiogenesis. Herein, based on the MMP-28 related research in recent years, the characteristics of MMP-28 and its role in tumorigenesis and development are reviewed, with a hope of providing reference for further study of the biological function of MMP-28.
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��־ǿ, ����, ����ѧ, ��Ԫ��, ��ռ��, ������, �� ��, �� �. MMP-28�����Լ���������������չ�е�����[J]. ������ѧ�о�, 2020, 24(5): 410-414. ZHAO Zhi-qiang, MA Fu-lin, CHEN Min-xue, NIE Yuan-hua, ZHU Zhan-di, KANG Bo-xiong, FAN Yong, WANG Chen. Characteristics of MMP-28 and Its Role in Tumorigenesis and Development. Life Science Research, 2020, 24(5): 410-414.
