Abstract：Abstract: As one of the important methods for treating malignant tumors, anti-angiogenesis therapy can significantly inhibit the growth and metastasis of tumors. However, resistance to anti-angiogenic drugs cannot be avoided in clinical application. At present, the research on drug resistance mechanism needs to be improved, and there are many obstacles in the development of clinical treatment. The research focusing on the mechanism of drug resistance, the search for new targets and integration of new therapeutic schemes will be of great significance for improving the clinical therapeutic efficacy of tumors. Herein, the latest progresses of anti-angiogenesis therapy against tumors were reviewed, including the mechanism of angiogenesis in tumor development, the application status of anti-angiogenic drugs, the related drug resistance mechanisms, and the future research strategies.
引用本文:
李 娜, 邢书娟, 黄国友, 冷 欢, 李 鹏, 王 琳. 抗肿瘤血管生成治疗的研究进展及应对策略[J]. 生命科学研究, 2020, 24(1): 62-67. LI Na, XING Shu-juan, HUANG Guo-you, LENG Huan, LI Peng, WANG Lin. Research Progress of Anti-tumor Angiogenesis Therapy and Its Countermeasures. Life Science Research, 2020, 24(1): 62-67.
2020,Vol. 24
