Abstract：Abstract: Cardiolipin (CL) is a unique phospholipid specific to the mitochondria. It influences the mitochon-drial structure as well as the activity of electron transport chain enzyme complexes. During apoptosis, CL redistribution will occur, including the content increase in mitochondrial endometrial lobules and its appearance on the cell surface. Also, apoptosis stimulation can accelerate the metabolism and circulation of CL, and reduce its content in mitochondria. When apoptosis occurs, CL, as a signal platform, has a great coordinating action especially with the proteins such as cytochrome c (CytC), caspase-8 and pro-apoptosis protein Bid. Herein, the important role of CL during apoptosis and the related progress in cancer research were reviewed.
引用本文:
张玉姣, 张 晶. 心磷脂对细胞凋亡作用的研究进展[J]. 生命科学研究, 2019, 23(6): 494-500. ZHANG Yu-jiao, ZHANG Jing. Research Progress of the Role of Cardiolipin During Apoptosis. Life Science Research, 2019, 23(6): 494-500.
2019,Vol. 23
