Abstract：Abstract: Neurofascin (NF) is a cell surface protein and a member of the immunoglobulin superfamily (IgSF). Different isoforms of the NF polypeptides such as NF155, NF166, NF180 and NF186 are generated by alternative splicing. The expression of these isoforms changes with the time and space, and they can work independently or interact extra- or intracellularly with many different proteins. The formation and stability of myelin sheath is assured by NF155 and caspr/contactin complex; NF166 and NF180 selectively regulate axon growth in immature neurons; high aggregation of NF186 confers stabilization of neural structures by interaction with ankyrin G at axon initial segments or nodes of Ranviers. These functional mechanisms are associated with many nervous system diseases, such as multiple sclerosis (MS), acute/chronic inflammatory de-myelinating polyneuropathy (AIDP/CIDP), etc. Herein, the structure, expression and biological functions of NF are reviewed.
引用本文:
胡 斌, 王成举, 屈福祥, 张雨平. 神经束蛋白的结构、表达和生物学功能[J]. 生命科学研究, 2019, 23(5): 412-416. HU Bin, WANG Cheng-ju, QU Fu-xiang, ZHANG Yu-ping. Structure, Expression and Biological Functions of Neurofascin. Life Science Research, 2019, 23(5): 412-416.
