Abstract：Abstract: To explore the kidney protective effect of Haematococcus pluvialis on alcoholic injury, mice were randomly divided into the control group, model group and groups treated with different doses (100 mg/kg, 200 mg/kg and 400 mg/kg) of the H. pluvialis powder. The alcoholic liver injury model was induced by intragastric administration with 50% ethanol for 7 days. About 16 h after the last administration, the animals were killed, and the sera and kidneys were obtained for determining the related markers, including the blood urea nitrogen (BUN) and creatinine (CREA), and superoxide dismutase (SOD), glutathione (GSH), malondialdehyde (MDA), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) in kidney. Compared with the model group, mice in treatment groups had a reduced kidney index, significantly decreased levels of BUN and CREA (P<0.01), significantly increased SOD activity and contents of GSH (P<0.01), and significantly de-creased contents of MDA (P<0.01), and also levels of inflammatory factors (TNF-α and IL-1β) (P<0.05). These results suggested that H. pluvialis had a significant kidney protective effect on alcohol-induced injury in mice.
引用本文:
魏芬芬, 王文娟, 贺青华, 张 波. 雨生红球藻破壁孢子粉对小鼠酒精性损伤肾脏的保护作用研究[J]. 生命科学研究, 2019, 23(2): 122-127. WEI Fen-fen, WANG Wen-juan, HE Qing-hua, ZHANG Bo. A Study of the Kidney Protective Effects of Haematococcus pluvialis Power on Alcoholic Injury in Mice. Life Science Research, 2019, 23(2): 122-127.
