Abstract：Antibacterial peptides tachyplesins (TPs), isolated from the hemocytes of horseshoe crabs and divided into five kinds, play an important role in immunological function in the limulus immune system and provide a natural defense barrier for the invasion of pathogens. Nearly 30 years of research shows that TPs exhibit broad-spectrum bioactivities, low cytotoxicity toward normal cells, and low levels of acquired resistance in microbes. As an entirely new type of peptide drug, TPs have become an intensely studied topic. Herein, the molecular structure of TPs, bioactivity against all kinds of microorganisms and tumor cells, action mechanisms and engineering expression are introduced. The application and the bottleneck of current research of TPs are also described.
引用本文:
李寒梅, 唐勇军, 王顺启, 代建国. 抗菌肽鲎素的研究进展[J]. 生命科学研究, 2018, 22(4): 338-344. LI Han-mei, TANG Yong-jun, WANG Shun-qi, DAI Jian-guo. Research Progresses on Antimicrobial Peptide Tachyplesins. Life Science Research, 2018, 22(4): 338-344.
