Abstract：Abstract: Pancreatic islet β cells are typical excitable endocrine cells that secrete insulin in response to increased glucose levels. Functional failure in β cells probably results in variety of diseases, particularly diabetes mellitus (DM). There has been growing research interest in insulin secretion and regulation of pancreatic β cells, especially in the ion channels, such as K+ and Ca2+ channels. However, less research has been done on Na+ channels, a kind of cation channels widely distributed in the cell membrane with multitudinous subtypes. These channels have proven to have a variety of physiological functions via participating in action potential formation, substance transportation and intercellular communication and so on. Here, the subtypes, physiological characteristics and functions of Na+ channels are reviewed to offer new insights for the research related to pancreatic β cells.
引用本文:
陈 冲, 魏姗姗, 王松华, 姚丽华. 胰岛β细胞中钠通道对胰岛素分泌的作用[J]. 生命科学研究, 2018, 22(1): 74-79. CHEN Chong, WEI Shan-shan, WANG Song-hua, YAO Li-hua. The Role of Sodium Channels in Insulin Secretion in Pancreatic β Cells. Life Science Research, 2018, 22(1): 74-79.
