Abstract��Abstract��Alzheimer′s disease (AD) is a chronic neurodegenerative disease in the CNS, the pathological features of which is characterized by senile plaques and neurofibrillary tangles. And its pathogenesis is very complex. Tanshinone��A is a liposoluble constituent extracted from Salvia miltiorrhiza, a kind of Chinese herbal medicine, and has a wide range of biological activities. Recent studies have found that tanshinone��A plays an important role in the prevention and treatment of AD by inhibiting the aggregation of β-amyloid protein, suppressing hyperphosphorylation of tau, and protecting neuronal cells from death. Combined with the latest research progress, the pathogenesis of AD and the prevention and treatment effects of tanshinone��A on AD were reviewed, and the basis for further development and utilization of this plant extract was also provided.
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������, ��ѩ��, �� ��, �� ��, ������. ����ͪ��A�����Ⱥ�Ĭ���������õ��о���չ[J]. ������ѧ�о�, 2017, 21(1): 59-63. LI Xiao-Xiao, WU Xue-Ling, ZHANG Kai, LI Lei, SUN Ya-Xuan. Research Progress of Tanshinone��A in Prevention and Treatment of Alzheimer′s Disease. Life Science Research, 2017, 21(1): 59-63.
2017,Vol. 21
