Abstract：Abstract: β-elemene, a self-developed anticancer medicine in China, has an obvious therapeutic effect on liver cancer, lung cancer and other malignant tumors due to low toxicity, high efficacy and wide-spectrum activity, while its role on human skin cancer has not been reported. Here, the anti-tumor activity of β-elemene was investigated on human melanoma cells. It was found that the proliferation of A375 cells was significantly inhibited by β-elemene (P<0.01) in a concentration- and time-dependent manner. Furthermore, related apoptosis proteins were detected by Western-blot, which showed that β-elemene inhibited AKT signal pathway to regulate Bcl-2 family proteins. It reduced the expression of Bcl-2, but significantly increased the expression of Bad, and in the meantime partially activated caspase proteins, thereby inhibiting A375 cell proliferation and inducing apoptosis.
引用本文:
蒋 革, 吴艳华, 罗 锋, 薛 勇, 李 清. β-榄香烯诱导人黑色素瘤A375细胞凋亡的研究[J]. 生命科学研究, 2017, 21(1): 55-58. JIANG Ge, WU Yan-Hua, LUO Feng, XUE Yong, LI Qing. Effect of β-elemene on Apoptosis in Human Melanoma A375 Cells. Life Science Research, 2017, 21(1): 55-58.
2017,Vol. 21
