Abstract：Abstract: Nonsense-mediated mRNA decay (NMD) is a mRNA quality-control mechanism in eukaryotic cells. NMD recognizes and degrades mRNAs that harbor a premature termination codon (PTC), thereby avoiding the accumulation of harmful truncated proteins. Besides, NMD affects stabilities of a plethora of physiological mRNAs, and regulates the concentrations of encoding proteins. Here, the recent studies on the substrates of NMD, regulators and its potential therapeutic significance for human genetic diseases were summarized.
引用本文:
胡建燃, 李 平. NMD机制及其对人类遗传病的治疗意义[J]. 生命科学研究, 2016, 20(6): 535-541. HU Jian-Ran, LI Ping. Mechanism of NMD and Its Potential Therapeutic Significance for Human Genetic Diseases. Life Science Research, 2016, 20(6): 535-541.
2016,Vol. 20
