Abstract：Abstract: In recent years, impressive progress has been made in the field of next-generation sequencing (NGS) technology, which brings a revolutionary advance in the whole biomedical research. Drug resistance is a very serious problem in the control of infectious diseases. NGS techniques can lead to deep understanding of the pathogenic microorganisms and their mutation mechanisms in humans, bringing a great impact on the biomedical research. Here, the mechanisms of different NGS techniques and their merits and drawbacks were summarized briefly. The applications and the current situation in the gene detection for drug resistance in infectious diseases, including malaria, AIDS, hepatitis, tuberculosis and influenza, were reviewed. Finally, comments were also made on the future development of NGS in studying drug resistance.
引用本文:
徐晓宇, 陈敬华, 程咏梅. 下一代测序技术在传染病耐药性研究中的应用[J]. 生命科学研究, 2016, 20(5): 460-465. XU Xiao-Yu, CHEN Jing-Hua, CHENG Yong-Mei. Application of Next-generation Sequencing Technology in the Research of Drug Resistance in Infectious Disease. Life Science Research, 2016, 20(5): 460-465.
2016,Vol. 20
