Abstract：Abstract: GATA-2, a member of the GATA-motif-binding family, plays key roles in hematopoietic development, functions by occupying GATA-binding sites of target genes. According to recent studies, the VentX gene, a mammalian homolog of the Xenopus xvent gene, is involved in mesodermal patterning and hematopoietic stem cells maintenance, and has regulatory roles in cellular senescence, proliferation, differentiation, and inflammation. To explore the relationship between VentX gene and GATA-2 and the regulatory functions of VentX in hematopoietic stem cells undergoing erythroid differentiation, promoter analysis of VentX in K562 cells was conducted and the results showed that GATA-2 can bind with two cis-regulatory elements of VentX promoter. Subsequently, the data were showed that overexpression of GATA-2 or VentX inhibited CD34+ cell proliferation in human bone marrow (hematopoietic) stem cells and induced erythroid differentiation of CD34+ cells. It provides us with a valuable clue for the source of red blood cells in clinic.
引用本文:
李 滨, 胡诗帆, 孙园园, 郭 驰, 张 健, 杨寅柯. VentX促进人类造血干细胞向红系分化[J]. 生命科学研究, 2016, 20(4): 283-289. LI Bin, HU Shi-Fan, SUN Yuan-Yuan, GUO Chi, ZHANG Jian, YANG Yin-Ke. VentX Induces Human Hematopoietic Stem Cells to Undergo Erythroid Differentiation. Life Science Research, 2016, 20(4): 283-289.
2016,Vol. 20
