Abstract：Abstract: FBXO39 is a member of the F-box protein family, and studies have shown that the protein is a newly identified cancer-testis antigen and closely related to tumorigenesis. In order to understand the biological function of FBXO39 gene, the expression level of FBXO39 in different tumor cell lines were detected and the recombinant eukaryotic expression vector was constructed. Then high throughput PCR array was performed to study the connection between FBXO39 and metabolism-related genes in MCF7 cells (low expression of FBXO39). And the selected genes were further verified in Ntera2 cells (low expression of FBXO39). The results showed that the expression of six selected metabolism-related genes (ALDH9A1, MCT1, DLAT, HMGCS, FASN, GLUL) was positive related to that of FBXO39 gene, which indicated that FBXO39 gene may play an important role in tumor metabolism.
引用本文:
刘智勇, 上官聪, 吴道兵, 刘晓雯, 赵 婷, 李 丹. FBXO39基因对肿瘤细胞代谢分子的影响[J]. 生命科学研究, 2016, 20(3): 202-207. LIU Zhi-Yong, SHANG Guan-Cong, WU Dao-Bing, LIU Xiao-Wen, ZHAO Ting, LI Dan. Effect of FBXO39 Gene on Metabolic Molecules in Tumor Cells. Life Science Research, 2016, 20(3): 202-207.
2016,Vol. 20
