Abstract：Abstract: The repair of DNA double-strand breaks (DSBs) is crucial to preserve genomic integrity and maintain cellular homeostasis. p53-binding protein 1 (53BP1) is an important regulator in response to DSBs. So far, new insights have been gained into the mechanism underlying the recruitment of 53BP1 to damaged chromatin. Also, new evidences have been revealed how 53BP1 promotes non-homologous end-joining-mediated DSBs repair while preventing homologous recombination. In addition, based on recent studies, the new model has been put forward that 53BP1 recruitment requires the direct recognition of a DSBs-specific histone code and its pathway choice is mediated by mutual antagonism with BRCA1. Here, the structural and functional characteristics of 53BP1 are reviewed and an overview of its role as a mediator in DSBs repair pathway is presented, as well as its recruitment to damaged chromatin.
引用本文:
张 敏, 范久波, 邵金辉, 胡祁生, 于弘钧. DNA双链断裂修复过程中的重要蛋白53BP1[J]. 生命科学研究, 2016, 20(2): 162-165. ZHANG Min, FAN Jiu-Bo, SHAO Jin-Hui, HU Qi-Sheng, YU Hong-Jun. 53BP1: a Key Protei n in Repair of Double-Strand Breaks. Life Science Research, 2016, 20(2): 162-165.
2016,Vol. 20
