Abstract：Abstract: RNA silencing or RNA interference is triggered by double-stranded RNA (dsRNA) and causes a sequence-specific degradation or suppression of the expression of genes containing sequences identical or highly similar to the initiating dsRNA. RNA silencing plays a role in regulation of gene expression and defense of invasive exogenous nucleic acids. RNA silencing is a conserved mechanism during evolution. RNA silencing in fungi has diverse pathways according to the different sources of small RNA. It includes quelling, qiRNA and MSUD. In different pathways, RNA silencing comprises three core proteins: Argonaute, Dicer, RdRP. The number of RNA silencing proteins in genome differs considerably among fungal species. This suggests the diversity of the fugal RNA silencing. RNA silencing appears to have been lost in some fungal species during evolution. Fungi which lost RNA silencing get the compatibility between killer system and RNAi-based antiviral defense during evolution.
引用本文:
李彦鹏, 邱立友. 真菌RNA沉默机制研究进展[J]. 生命科学研究, 2015, 19(6): 547-553. LI Yan-Peng, QIU Li-You. Progresses on the Mechanism of RNA Silencing in Fungi. Life Science Research, 2015, 19(6): 547-553.
2015,Vol. 19
