Abstract：Abstract: Long noncoding RNAs (lncRNAs) are transcribed from a large class of genes in human genome, and are emerging as key regulators of multiple biological processes at transcriptional, post-transcriptional and epigenetic levels. Many lncRNAs are highly expressed in the central nervous system (CNS) in a specific manner, suggesting that they might play important roles in CNS development and diseases. Cerebral ischemic stroke significantly alters lncRNA expression profiles in CNS, indicating that the disregulation of lncRNAs may contribute to the complex pathological process after ischemic stroke. Taking further insights into the function of lncRNAs is helpful for us to construct molecular regulatory networks and to open a new field of therapeutic targets in ischemic stroke. Although there are few reports about lncRNAs in ischemic heart diseases, much less is currently known about lncRNAs in ischemic stroke. Current progresses are summarized on the role of lncRNAs in ischemia-reperfusion injury, apoptosis/anti-apoptosis, neurorestoration and neurogenesis. Finally, potential research directions of lncRNAs and ischemic stroke in the future are proposed.
引用本文:
冯维熙, 孙秀兰. 长链非编码RNA调节缺血性脑卒中损伤和修复的研究进展[J]. 生命科学研究, 2015, 19(5): 457-464. FENG Wei-Xi, SUN Xiu-Lan. Progresses on Long Noncoding RNAs Regulating the Development of Ischemic Stroke. Life Science Research, 2015, 19(5): 457-464.
2015,Vol. 19
